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Clinical and Experimental Hypertension Volume 30, 2008 - Issue 2
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Association between Genetic Variation in Transforming Growth Factors β1 and β3 and Renal Dysfunction in Non-Diabetic Chinese

Bang-Chuan Hu Department of Hypertension and Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, China
,
Shao-Li Chu Department of Hypertension and Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, ChinaCorrespondenceshaolichu@163.com
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Gu-Liang Wang Department of Hypertension and Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, China
,
Ping-Jin Gao Department of Hypertension and Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, China
,
Ding-Liang Zhu Department of Hypertension and Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, China
&
Ji-Guang Wang Department of Hypertension and Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, China
Pages 121-131 | Received 17 Apr 2007, Accepted 23 Aug 2007, Published online: 03 Jul 2009
 
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Abstract

Genetic variants of transforming growth factor (TGF) β1 have been reported to be associated with diabetic nephropathy. Few studies investigated polymorphisms in the TGF-β1 and TGF-β3 genes in relation to renal dysfunction in non-diabetic subjects. In all, 601 non-diabetic Chinese were genotyped for the TGF-β1 T869C and TGF-β3 IVS3-98G>A polymorphisms by PCR-restriction fragment length polymorphism and real-time allele-specific PCR, respectively. Renal dysfunction was defined as a predicted glomerular filtration rate (GFR) of 60mL/min/1.73m2 or less. 24-hour urinary albumin excretion was measured by an immunonephelometric assay in 352 hypertensive subjects. Our study sample included 184 (30.6%) women, 396 (65.9%) hypertensive patients (65.9%), and 94 (15.6%) patients with renal dysfunction. In men but not women, the TGF-β1 TC genotype was significantly (p = 0.0005) overrepresented in patients with renal dysfunction (52.2% vs 36.8% in subjects with normal renal function). Accordingly, in men, with adjustment for age, body mass index, and systolic and diastolic blood pressure, serum creatinine concentration was significantly (p ≤ 0.03) higher in the TC heterozygotes than TT and CC homozygotes. Furthermore, in 231 male hypertensive patients, with similar adjustments applied, 24-hour urinary albumin excretion was significantly (p = 0.02) higher in the IVS3-98 AA homozygotes than G allele carriers. In further multivariate regression analysis, only in men, TGF-β1 and TGF-β3 genotypes as independent predictors had statistically significant effect on serum creatinine (p = 0.007) and urinary albumin excretion (p = 0.022), respectively. Our study demonstrated the associations of genetic variants in the TGF-β genes with renal dysfunction and albuminuria in non-diabetic Han Chinese men but not women.

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